Biocatalysts Limited

To use novel Ultra Scale-Down methods to speed the creation and scale-up of processes for fermentation based industrial enzyme manufacture, increasing efficiency and productivity.

"Biocatalysts Ltd are an SME located in Cardiff UK. Using microbial fermentation technology, we manufacture high-value enzymes that are sold into the following market applications: (i) used as processing aids in the manufacture of pharmaceutical intermediates (ii) used as processing aids in the manufacture of food ingredients (iii) used for DNA processing...

Enzymes are biological molecules that facilitate chemical reactions in living cells. Many products in the fine chemical, food, flavour & fragrance, pharmaceutical and biotherapeutic industries use enzymes in their manufacturing processes. The majority (more than 75%) of enzymes currently used in industrial processes are hydrolytic in action. Among these, ...

Only a tiny fraction (~1%) of all microorganisms can currently be grown in the laboratory and hence have their DNA sequenced. Thus, there is a huge wealth of genetic sequence data still to be discovered from environmental samples of the remaining 99% of uncultured microorganisms. The field of metagenomics directly samples microorganisms living in the envi...

Enzymes are biological molecules that facilitate chemical reactions in living cells. Many products in the food, fine chemical, flavour & fragrance, pharmaceutical and biotherapeutic industries use enzymes in their manufacturing processes. Many enzymes on the market are isolated from their original wild-type organism, many more need to be produced in a dif...

This project is designed to manufacture a useful class of organic chemicals, used in paint formulations, starting with a waste by-product from the chemical industry and transforming it to the desired material by use of biocatalysis. The current chemical route employs caustic soda and sulphuric acid, and as well as producing the desired product, also co-pr...

A consortium comprising of Aesica Pharmaceuticals, Biocatalysts Ltd, CatScI Ltd and Charnwood Technical Consulting has been established as part of the Sustainable High-Value Chemical Manufacture through Industrial Biotechnology (IB) 2 competition from the TSB. The key goal of the project is to identify novel IB routes to an active pharmaceutical ingredien...

The primary objective of this project is to develop speciality recombinant enzymes for use in the manufacture of baked goods. This feasibility project focuses on the development of recombinant enzymes, which are not currently available on the market. This study will involve the cloning and expression of genes from the enzyme of interest into multiple expr...

Biocatalysts Ltd. will undertake a project to develop a novel enzyme for production of high value speciality yeast extracts. These speciality yeast extracts are valued for their natural taste intensification properties, ability to mask undesirable bitter notes, creation of umami flavours and their use in reduced salt content food recipes.

This feasability study is designed to integrate two emerging technolgies – (1) Bioinformatics assisted design of novel enzyme characteristics, (2) Rapid in vitro screening of enzyme variants prior to expression in host microorganisms and subsequent commercial scale enzyme production. By using initial in vitro protein synthesis to test enzyme variants we w...

Biocatalysts Ltd will undertake a project to develop new thermolabile enzymes for production of high value food chemicals. As part of the project the company will work with the University of Swansea to use novel in silico modelling techniques to identify enzyme structures that have optimal performance with respect to both specificity and thermal lability.

Leukolectin is a novel, patented molecule, exhibiting (in pre-clinical tests) remarkable benefits for the treatment of a range of skin, autoimmune and gastrointestinal disorders. Leukolectin is absent in many disease states, suggesting that its presence is critical for preventing the listed ailments. By creating a range of topical and oral medicaments con...