The Automation Partnership (Cambridge) Limited

To design and develop novel bioprocesses and vessels for optimal therapeutic protein and cell therapy production using the automated ambr250 bioreactor platform.

The project aim is for TAP Biosystems, The Cell Therapy Catapult and University College London to develop a small scale benchtop bioreactor that can be applied to cell therapy appliations, to test and validate the performance of the new bioreactor system with exemplar cell line expansion processes representative of both allogeneic and autologous therapies...

We plan to develop a novel ‘living nerve growth guide’ as an off the shelf therapy to treat peripheral nerve injury, which can cause lifelong pain and disability and is a significant unmet medical need. Our therapy would substitute for an autograft, the current ‘gold standard’ for peripheral nerve repair. Partners TAP Biosystems and The Open University ha...

We plan to develop a novel, automated cell culture system specifically designed for iPSC and autologous cell culture. Early stage iPS cell culture is very labour intensive since cells must be monitored and fed daily for many weeks. For clinical applications cells must be cultured in a GMP clean room environment, with high staff and infrastructure costs. O...

TAP Biosystems and UCL Institute of Ophthalmology are developing a novel, patented technology (RAFT) that enables 3D tissue equivalents to be manufactured from collagen simply and reproducibly. The RAFT process creates tissue-like architectures that we are using to develop a corneal therapy - with embossed surface topography to replicate the in vivo stem ...

Awaiting Public Summary

The aim is to develop a process which can distinguish good from bad induced pluripotent stem cells (iPS cells) in terms of their differentiation capacity. Batches of iPS cells derived from multiple patient tissue samples will be analysed and grouped in terms of their ability to differentiate into the three cell lineages (endoderm, mesoderm and ectoderm). ...

TAP Biosystems and UCL Institute of Ophthalmology are developing a novel, patented technology (RAFT) that enables 3D tissue equivalents to be manufactured from collagen simply and reproducibly. The RAFT process creates a tissue-like architecture that we are using to develop a corneal therapy - with embossed surface topology to replicate the in vivo stem c...

Awaiting Public Summary

The project seeks to design and build a flexible robotic platform to automate incubation and processing of hundreds of mammalian cell cultures growing in shake flasks, with integrated cell growth and metabolite analysis. Shake flasks model larger scale bioreactors, have ample volume for frequent sampling for analysis and support process development and ce...