Plasticell Limited

Allogeneic cell therapies - where a single donor-derived cell line is used to treat many patients - represent a transformative opportunity in modern medicine to address a wide range of conditions from cancer to neurological disorders. These therapies are often based on growing ('expanding') induced pluripotent stem cells (iPSCs) and then transforming ('di...

Immunotherapy, the modulation of a patient's immune system to fight against diseases such as cancer, holds great promise but is still far from being widely usable for solid tumors. This is due to several reasons: cancers are good at evading the host immune system; patients not always have enough immune cells to use for therapy, and using cells from other ...

Modern therapies are often concerned with using human cells as therapeutic modalities. Recent breakthroughs in the treatment of leaukemia and lymphoma are associated with the administration of patient's own isolated T-lymphocyes, modified at the laboratory to recognise and kill tumour cells. However, such therapies have strong side effects, require time f...

Many patients with blood disorders, such as cancers, are often treated by receiving a bone marrow transplant from another person. Usually, this donor has to be a blood relation or have a compatible tissue type to ensure the transplant is not rejected. However, finding such a match is not always possible. For some years now, parents have been donating the ...

Cancer is still a leading cause of death worldwide, and is thought to have been responsible for 9.6million deaths in 2018 (about 1 in 6 deaths). Unfortunately, despite improvements in cancer care and treatment, the incidence and the number of deaths from cancer are set to increase along with an aging and growing population. There is therefore a need for m...

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Many patients with blood disorders, such as cancers, can usually be treated by receiving a bone marrow transplant from another person. Usually this donor has to be a blood relation or have a compatible tissue type to ensure the transplant is not rejected. However, finding such a match is not always possible. For some years now, parents have been donating ...

Primary Immunodeficiency disorders are rare genetic defects of blood cells that affect children and often lead to early death. Up to a few years ago the only proven cure for those type of disorders was haematopoietic stem cell (HSC) transplantation, although complicated by the need to identify a suitable donor and severe side effects. Recently developed t...

Blood transfusion is one of the most common clinical therapies and plays a critical role in prevention and management of many health conditions and diseases. Around 90 million red blood cell transfusions are carried out every year and this rising demand is dependent on a limited supply of healthy donors. The supply problem is compounded by other issues in...

Patients with blood cancers can usually be treated by receiving a bone marrow transplant from another person. Usually this person has to be a blood relation or have a compatible tissue type to ensure the transplant is not rejected. However, finding such a match is not always simple. For some years now, women have been donating the blood found in the umbli...

Platelets are an essential component of blood, involved in homeostasis, clotting and wound healing. Certain medical treatments (esp. chemotherapy) cause a severe reduction in platelet count leading to uncontrolled bleeding. This can be treated with transfusions of platelets isolated from donor blood, but in approximately 15% of patients, repeated challeng...

Brown adipose tissue (BAT) is a rare type of fat that in contrast to abundant white adipose tissue does not store eneregy but burns it to generate heat. BAT mass and function is inversely correlated with obesity and BAT has also been shown to improve glucose defects observed in diabeties, above what would be expected from weight loss alone. Therefore ther...