Mologic LTD.

**HERALD (Health Enhancement through Rapid Assessment of Livestock Diseases)** is a collaborative project delivering fast, practical diagnostics for Johne's disease (JD) in cattle, with limited feasibility work preparing the platform for future bovine tuberculosis applications. JD is widespread and costly for dairy and beef producers, undermining animal w...

Urinary Tract Infections (UTIs) and antimicrobial resistance (AMR) pose significant global health threats, characterised by high incidence and mortality. However, in Sub-Saharan Africa (SSA), there is often a lack of accessible diagnostics to guide proper treatment and therapy monitoring. Our objectives are as follows: (1) Develop and validate a two-tier ...

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The current SARS-CoV-2 pandemic has highlighted the need for access to rapidly produced, reliable diagnostics with the required sensitivity and specificity at a cost that makes these widely accessible to lower and middle income (LMICs) as well as higher income countries. Protein based diagnostic development and manufacture is reliant upon the availability...

This project addresses the need for new vaccines for global epidemics by the development of a virus-like particle (VLP) based platform technology to deliver a vaccine against Q Fever. The causal agent of Q fever, Coxiella burnetii has been identified as an agent of concern due to its low infectious dose, the ability of the organism to survive for long per...

COPD is the second most common cause of emergency admissions in the UK, responsible for one in eight (130,000) acute adult medical admissions. It is a global problem, with 210 million sufferers and 3 million deaths annually (WHO, 2009). There are 1.2M COPD patients in the UK. Patients with COPD have daily symptoms, a poorer health status, reduced exercise...

Reducing fungal fruit rot is a priority in strawberry production in the UK; annual economic losses due to fungal rotting are usually between £30 to £60M. Rot is mainly caused by Botrytis cinerea, Mucor spp. and Rhizopus spp., with their relative prevalence varying over time and growing site. Most strawberry production in the UK is under protection where t...

Sepsis is one of the most common deadly diseases and one of the leading causes of death in the developed world exerting a huge human and economic toll. In the UK there are over 100,000 cases and 37,000 deaths annually. Rapid diagnosis is critical to the effective treatment of the patient and offers the prospect of reduced mortality but existing diagnostic...

Virus-like particles (VLPs) are a flexible delivery platform that provides potential for presenting multiple antigens to the immune system concurrently. Hepatitis B core antigen self assembles to form highly stable, immunogenic VLPs in a relatively low cost yeast expression system. The viral protein can be adapted to display foreign antigens on spikes tha...

Our target is to develop a simple, easy to use, diagnostic system for use in the home by COPD patients to gain early warning of acute exacerbation (AECOPD) and stratify them to the most suitable and effective therapy. This will determine the use of antibiotic, anti-inflammatory or bronchodilator medication (combinations of some of these might be required)...

A simple, easy to use, rapid, inexpensive, effective, point of care (POC) immunodiagnostic system for early confirmation of sepsis in at-risk patients is to be developed and validated. The biomarkers will include IL-6, C-reactive protein and soluble ICAM-1. These known biomarkers will be integrated via a new algorithm with other physical/clinical indicato...