Centre For Process Innovation Limited

Our project, Novel Biocatalysts for Sustainable Manufacture of Pharmaceuticals, is developing a greener, safer way to produce important pharmaceutical chemicals. Traditional chemical processes for adding nitro groups to molecules require harsh conditions and generate hazardous waste. We are replacing these methods with enzymes called nitrating cytochrome ...

Self-amplifying RNA (saRNA) is a new class of therapeutic RNA which offers major sustainability benefits compared with conventional RNA, including higher potency and substantially reduced dose requirements. This supports greener manufacturing and lowers resource use across production, storage, and administration. However, these same properties mean that a...

As AMM therapies become more mainstream, conventional measurement and analysis technologies are increasingly pushed beyond their traditional usage boundaries. LiquiSensor is an emerging technology with strong potential for pharmaceutical process monitoring, but its current implementation presents challenges in this new field. Personalised medicine relies ...

The **S**mart **P**ersonalised **H**ealthcare: **E**valuation, **R**esponse and **E**ngagement (**SPHERE**) is a UK-wide collaboration led by the Catapult Network that aims to make personalised and preventative healthcare a practical reality for everyone. The vision: _"A healthcare system where every individual receives the right diagnosis, the right trea...

The pilot Centre of Expertise for Advanced Materials and Sustainability (CEAMS) (formerly Sustainable Materials Translational Research Centre (SMTRC)) is a collaboration funded by the Innovation Accelerator (IA) programme (2023-2025) via Greater Manchester Combined Authority (GMCA) and Innovate UK (IUK). It is led by major regional and national stakeholde...

ErebaGen harnesses chemistry from Nature and its project aims to transform hazardous chemical manufacture through the use of sustainable biological processes. The innovation focus and need is aromatic nitration, a critical chemical step in production of numerous pharmaceutical intermediates. This reaction proceeds rapidly, generates heat, can get out of c...

Traditional sunscreen formulations are highly effective for the prevention of skin cancer (the 5th most common cancer in the UK). However, the UV protective active ingredients used in their formulations have a number of health and environmental issues. Some sunscreen actives can absorb into the skin, leading to hormone disruption and skin sensitivity issu...

Currently antibody medicines require ultra-cold-chain during production and storage to prevent spoiling due to aggregation at the molecular level, which can occur at any stage from factory to patient. This project uses game-changing, proprietary Ensilication technology to remove this cold-chain dependence in the manufacturing and supply of antibody treatm...

Therapeutic peptides are set to dominate the top-selling drugs list over the next decade. Incretin mimetics such as Semaglutide (brand names Ozempic/Wegovy/Rybelsus) and Tirzepatide (brand names Zepbound/Mounjaro) are projected to make up 5 of the top 10 selling drugs by 2030, with combined sales of $116Bn. Each of these active pharmaceutical ingredients ...