Cell Guidance Systems Limited

Cell Guidance Systems' mission is to improve the delivery of cancer immunotherapeutic drugs, focussing on late-stage prostate cancer, a disease which kills 12,000 men each year in the UK. The body's immune system can recognize and destroy cancerous cells. However, cancers gradually develop mechanisms to evade the immune system, ultimately undergoing uncon...

Purified recombinant proteins are widely used in research, medicine, and industry. Cytokines, hormones and antibodies have been important in reshaping the field of medicine over the last half-century. How these proteins are manufactured, stored and delivered to their site of action (e.g. diseased tissue) is fundamental to their utility. We have developed ...

World meat consumption has tripled since 1970 and will increase a further 76% by 2050\. In the future, there will not be enough meat available for the world's population. This shortage will hit low-and-middle-income countries, where meat is an important but limited source of nutrient-dense protein, vitamins and minerals, especially hard. Over 80 billion a...

The mechanism by which a drug travels following administration (e.g. by intravenous injection) to reach its molecular target is critical to efficacy. Innovations in drug delivery have been fundamental to many medical advances. Most recently, RNA drugs, including widely used vaccines against SARS-CoV-2, have entered the market. RNA drugs required novel mec...

Innovative growth factor functionalized products for the lifescience research market

To embed underpinning knowledge of biomaterials and capability in hydrogel engineering, to enable development of bioinks, 3D matrices and functionalised microcarriers for incorporation into and enhancement of our Polyhedrin Delivery System sustained release protein technology.

"Parkinson's disease (PD) is a neurodegenerative disorder that affects around 1% of individuals over the age of 55\. The disease is associated with loss of a relatively small number of cells, called dopaminergic neurons (DNs), which are located deep in the centre of the brain. PD is a progressively debilitating disease with patients currently treated usin...

Awaiting Public Project Summary

Osteoarthritis (OA) is a huge problem to the affected individual and the healthcare system. In the UK, 29% of adults over 45 have OA, of which 9% is severe (Arthritis Research UK) – equating to 6.5m people. It can cause severe pain in joints, for example the hip and the knee where and can cause great difficulty walking. No current treatment exists for OA ...

The majority of vaccines have a narrow temperature window within which they must be stored to maintain functionality. The development of vaccines that are stable at ambient temperatures is a major challenge in their delivery to the people that need them the most, in low-income settings where the refrigeration infrastructure required is poor. We have devel...

Cell Guidance Systems is planning to develop a protein purification technology which has potential to significantly impact the way proteins are both manufactured and used for cell research and disease therapy. The technology is significantly differentiated from alternative protein manufacturing technologies and addresses very significant, multi £bn resear...

The manufacture of cells in a controlled and reproducible manner is a critical challenge in regenerative medicine. We will develop an integrated platform technology for the rapid identification of novel, efficient stem cell expansion and differentiation protocols that are optimised for translation to clinical grade manufacturing. Several innovative techno...