Tecrea Limited

Recurrent urinary tract infections (UTIs) are a significant issue affecting many women worldwide. Despite being a long-standing problem, the primary treatment method -- antibiotics -- has remained unchanged for many years. While antibiotics are effective in many cases, they bring numerous side effects and contribute to antimicrobial resistance (AMR). Alth...

Endometritis is among the most important and challenging diseases in the dairy industry, with significant animal welfare, economic, and food security consequences. The current standard of care is to administer antibiotics; however, there is growing concern about acquired antimicrobial resistance ("the slow-moving pandemic") and broad agreement that altern...

Age-related macular degeneration (AMD) is a major public health challenge that affects millions of older adults worldwide, causing irreversible vision loss, reducing quality of life. The standard of care is to administer anti-VEGF antibodies by injections into the eye, which are effective in slowing down the progression of the disease but have several dra...

Viral vectors are central to the gene therapy revolution of medicine and have demonstrated transformative patient benefits. The manufacturing of viruses is inherently complex, where a key challenge is the introduction of virus encoding DNA into producer cells grown in culture. This area of high-value manufacturing is exciting, strategically important, and...

The standard method for detecting SARS-CoV-2, the virus responsible for causing COVID-19, is called "RT-PCR" (reverse transcription, polymerase chain reaction). RT-PCR works by directly detecting the virus genetic material in patient samples and as such it requires the virus genetic material (its genome) to be intact in these samples in order to work. Bec...

"NanOptima has a mission to improve efficacy and safety of ophthalmic medications by improving delivery of APIs. As populations grow older, more and more people need treatment for sight-threatening eye conditions. ""The lifetime risk, of sight loss or blindness requiring intervention or treatment, is estimated to be: nearly **1 in 5 people for permanent s...

This project aims to develop a method to track and measure a polymer in skin, blood and milk. The polymer (Nanocin™) is being used by Tecrea Ltd and partners to improve drug delivery for human and animal health applications. As with any drug development program, it is important to be able to accurately measure the ingredients. The experts at NPL will work...

The project aims to develop a scalable bio-process for recombinant virus production. Adeno Associated Virus (AAV) is a safe and effective gene therapy vector and growing demand for therapy development cannot be met by current methods. Conventional technologies used for safe AAV production are inefficient and often highly toxic to the process. These proble...

Tecrea and Leeds University BioScreening Technology group will collaborate to establish the feasibility of using peptide aptamers based on the Leeds's Andiron platform to modulate intracellular oncology targets. In particular KRas and Bcl-xL. The key innovations are the use of Tecrea's safe nanoparticle based delivery system combined with a stable peptide...

This project combines three partners (2 industrial, 1 academic) with complementary expertise to develop a product for cancer treatment. The research will focus on the development of an injectable formulation based on nanoparticles with the ability to deliver a payload to cancer cells. This ability is based on the presence of chemical groups, which can sel...

The project aims to improve the stability and cell entry properties of messenger RNAs, which encode functional proteins. mRNAs are natural biomolecules that may become extremely valuable in healthcare if cell delivery properties can be improved. Delivery is a challenge because these biomolecules are generally too large to enter cells easily where many of ...

The project is a collaboration between Phytoceutical and Tecrea, a bioscience technology company, to test the feasibility of novel formulation and delivery methods of actives to the skin. Phytoceutical has expertise in the areas of natural products used as ingredients in skin treatments and Tecrea Ltd has expertise that may help to stabilise such products...