Ingenza Limited

Project lead, Ingenza Ltd. will apply cutting edge engineering biology to advance the commercial utility of a non-conventional yeast with properties very suited to industrial use (e.g. rapid growth, feedstock versatility, high product tolerance) but severely lacking to date in the methods and genetic tools necessary for effective biotechnology application...

Our project addresses the critical need for viable, sustainable biomanufacturing processes and accelerated development of protein therapeutics, emphasising the importance of predictability when designing DNA sequences to produce valuable heterologous proteins efficiently, using recombinant organisms. Leveraging insights from natural codon usage profiles, ...

Amprologix is a company developing novel antibiotics to meet the global threat of antimicrobial resistance (AMR). AMR happens when bacteria become resistant to antibiotics and results in treatment failure and increased death from 'drug resistant' infections. These infections killed over 1.2 million people in 2019 and new antibiotics are urgently needed. I...

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This project will apply world-class biotechnology to deliver the world's first bio-based commercially viable manufacturing process for methacrylate ester (MAE), the building block of poly-methylmethacrylate (Perspex(r)) with a game-changing improvement in sustainability. The collaboration of Mitsubishi Chemical Corporation (MCC --Japan), Lucite Internatio...

Carbon utilisation in bioethanol production by the yeast _Saccharomyces_ _cerevisiae_ suffers significant efficiency losses because the organism also produces glycerol as a (waste) co-product to help maintain its osmotic balance. This low value waste product compromises bioethanol yield by up to 5%. Others have tried to address this problem, employing yea...

This project will have a disruptive impact on the sustainability and cost effectiveness of ethanol production for the renewable fuels sector, while improving the environmental footprint and climate-change impact of the entire ethanol industry. It will address multiple economic, social, environmental and political needs. It will achieve this through innova...

Oesophagogastric cancer (cancer of the food pipe and stomach) is the fifth most common cancer in England and Wales with 16,000 new cases diagnosed every year. Currently only 15 out of every 100 patients diagnosed with this type of cancer live beyond 5 years. When oesophagogastric cancer is detected it is often in an advanced late stage. This is because sy...

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This project aims to support a novel and vital alternative strategy to realise broad population immunity to the SARS-CoV-2 virus (the cause of COVID-19 disease) in the event that the adenoviral-based vaccines currently under development in the UK prove insufficiently efficacious, safe and/or cost-effective. It will show that yeast-based production of a ke...

This project aims to demonstrate the significant safety and cost benefits of a novel enzyme-enhanced test-strip that rapidly substantiates the correct placement of nasogastric feeding tube in infants and neonates - patient sub-groups for which tube placement errors confer very significant clinical risks and costs. Several hundred thousand nasogastric (NG)...

"Bio-inspired processes will have a major impact on the challenges of the global society in 21st century, including those associated with environmental sustainability. The employment of biocatalysts in industrial processes is expected to boost a sustainable production of chemicals, materials and fuels from renewable resources. The scope of this proposal i...