This Project will demonstrate a novel multi-pathogen single tube assay that can be operated at the Point-of-Care by clinical staff using a new automated Polymerase Chain Reaction (PCR) thermocycler. The Project will seek to take advantage of the multi copy characteristics of a universal conserved bacterial gene using Smiths Detections’s proprietary LATE-PCR and Thermalight technology and Enigma’s new PCR thermocycler. If successful the test will, from a raw blood sample, be able to categorise an infective agent into gram positive, gram negative or Candida with a 95% Negative Predictive Value (NPV). Furthermore, it will be able to identify the infection from a selection of the 20 most prevalent organisms. The availability of such a Point-of-Care test in A&E and ICU departments would, quite simply, transform the clinical diagnosis and management of Sepsis.

Safe and legal global transport is essential to human welfare, but it demands that customs authorities implement security regulations with a special focus on illicit goods. To enable enforcement of regulations tackling illicit goods trafficking, customs authorities have expressed their need for portable, affordable, non-intrusive, reliable screening technologies aiming to facilitate on-site and rapid inspections. The current technologies are mainly based on X-ray screening, but have its limitations in detecting illicit goods, are very expensive and the process is time consuming. This makes that currently less than 5% of the containers may be inspected, which is undesirable for customs authorities and society. In the METEOR project, the consortium will develop a prototype of a portable and versatile air sampling-based screening system. This will enable customs administrations worldwide to rapidly and reliably inspect for the presence of illicit goods. The METEOR technology will provide a new concept of cargo screening detector with a highly efficient air sampling technique and the ion mobility multidetector sensing technology. The METEOR analyser relies on a very innovative concept of a multi-detector differential mobility analyser (DMA), that classifies molecular ions based upon their electrical mobility. This generates a chemical fingerprint of the samples, and after the processing with non-targeted screening techniques, it is possible to accurately classify and detect the threats. The focus will be on the detection of illicit drugs, but also explosives and other substances. The goal is to develop the METEOR technology up to TRL7, and validate it in the operational environment. This is done by the four customs administrations (The Netherlands, Belgium, Spain and Ireland) involved in the project, that cover some of the main ports in Europe

Awaiting Public Summary

The public description for this project has been requested but has not yet been received.

Awaiting Public Summary

Awaiting Public Summary