Smithkline Beecham Limited

Clavulanic acid (CA) is a beta-lactamase inhibitor able to potentiate the antibacterial activity of penicillins against otherwise resistant bacteria. It is the product of complex biological factories found naturally in Streptomyces clavuligerus, and is currently made industrially via fermentation using a strain that has been through successive rounds of n...

Natural or engineered biosynthesis can replace chemical synthesis with more environmentally friendly, sustainable bio-manufacturing processes to generate small molecule products such as pharmaceuticals. Although expression systems for recombinant proteins have been developed for laboratory scale and for commercial expression of very high value products su...