Asymptote Limited

"**Advance Therapy Medicinal Products (ATMPs)** **are a new generation of treatments which use patients' cells as 'drugs' to treat a variety of diseases.** Although encouraging results have been reported, this technology is complex, expensive and currently only available to small numbers of patients. In **2018** the **UK** have formed **a network of three...

"Advance Therapies are a new generation of treatments which use patients' cells as 'drug' to treat a variety of diseases. Although encouraging results have been reported, this technology is complex, expensive and currently only available to small numbers of patients. We have formed the Innovate Manchester Advanced Therapy Centre Hub (iMATCH); this is a gr...

"The Northern Alliance Advanced Therapies Treatment Centre (NAATTC) is a group of NHS hospitals and services. NAATTC has a wide geographical reach across Scotland and the North of England and is responsible for the health care of 15 million NHS patients. Advanced therapies are becoming increasingly available with a growing number of companies developing t...

"ATMPs, which can be _cell or gene therapies_, show great potential in treating patients with conditions that cannot be cured with current treatments. These include arthritis, liver disease, several types of cancer, and diabetic ulcers. ATMPs are just beginning to be available, with the UK playing a leading role. However, even when new ATMP therapies are ...

Cancer specific Adoptive T-Cell therapy (ACT) is a form of personalised medicine that harnesses the power of the patient's immune system to direct tumour-specific T-cells to kill cancer cells. The field of adoptive T-cell therapy has approached a point where the pre-clinical promise is now a clinical reality. Since the first report of use of TIL therapy i...

In regenerative and transplantation medicine medicine a bottleneck limiting progress is that tissue engineered constructs cannot be manufactured on demand. Cryopreservation aims to overcome this problem, however whilst success has been achieved with cell suspensions, successful scale up of construct size has remained elusive. No methods exist that can pro...

The project brings together the technological expertise to develop a cost effective mass production and delivery a more effective biological solution to control pests with expertise in fungal cell processes and whole organism survival to ensure product long term shelf life whist retaining organism function. It combines improved product formulation with ef...

Cancer treatments are being transformed by T-Cell therapies and present a huge global opportunity. However, logistical problems transporting the cells to and from the patient are restricting the industry’s growth. There is an urgent need for a portable shipping device that combines; controlled sample freezing, temperature controlled shipping, data logging...

This application relates to the development of the consumables and associated equipment to allow the widespread clinical delivery of a bioartificial liver (BAL). Since the liver is one of the few organs that can repair and regenerate, therapies enabling regenerative medicine, that is creating living functional tissues to repair or replace organ function l...

The objective of this project is to examine the feasibility of employing fluorescent proteins as a visual means of monitoring the glass transition (Tg) of the solutions in which stem cells are stored and transported as they pass through the cold chain. The Tg of such solutions is the single most critical determinant of patient safety: at temperatures high...

The project will develop a consistent, highly functional and biologically robust technology for the cryopreservation of cells in microtitre plates. These cells will be used in subsequent screening applications, for example drug safety testing. Many cell types are used for screening applications, with hepatocytes being widely used to investigate drug safet...

In this project we propose to develop a portable, self charging , cryogenic vessel for the shipment and short term storage of frozen material. In particular, live vaccines for use in third world. Examples of the material include live attenuated vaccines in development for treatment of human malaria and leshmaniasis as well as several veterinary products. ...