Public Funding for King's College London Business Limited

Touch is fundamental to almost all human interaction with the world and other humans, yet it is an under exploited aspect of human computer interaction. Haptics is the study of how humans physically interact with the world around them and haptic devices allow physical interaction with computer simulations. There are many potential uses for haptics: education, training, rehabilitation, entertainment, disability access (visual and motor impairments), creativity and communication. Advanced haptic interfaces are beginning to transition from research to to commercial applications but many challenges remain before they can be practically used in daily life. Generic Robotics Ltd. are experts in Haptic interfaces and have partnered with the internationally renowned Dental Institute at King’s College London to explore the application of haptics in the training of dentists.

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Most new pharmaceuticals under development are injectable large molecule biopharmaceuticals. Unstable in solution they require either reconstitution or costly and often impractical cold chain logistics. Current reconstitution devices are manufactured using an inefficient process and can suffer from poor mixing. There is a need for a reconstitution injection device which reliably and quickly reconstitutes and which can use more efficiently manufactured bulk lyophilised powder. Traditional reconstitution devices are complex requiring medically trained personnel to administer: home use lowers administration cost. 3P have an innovative device concept: prototypes have shown initial feasibility. The project will further develop the product with focus on the innovative mixing and auto-injector functionality. Quantitative data on the efficiency of mixing of the powder and liquid will be obtained and compared with a current standard industrial dual chamber syringe.

Growing healthcare costs and poor patient outcomes is driving increased interest in collaboration to support stratified medicines as a means to deliver targeted, safe and cost effective treatments. Research into stratified medicines is severely curtailed by poor access to high quality patient data and the deluge in associated genetic, molecular and image information. The innovative Acropolis platform will provide the essential informatics infrastructure to support secure stratified medicine research and collaboration, including data handling, storage, retrieval and analysis services that will acquire, pseudonymise and integrate data from a wide variety of diverse sources. Acropolis has a strong consortium led by R&D data management firm IDBS, supported by hosting firm Quantix and leading cancer institutes at Manchester and King’s Health Partners. The Acropolis consortium has all the components to successfully support translational research activities and will ultimately help deliver improved treatment of cancer and other diseases across global healthcare systems.

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Awaiting Public Summary

This aim of this project is to develop novel devices and imaging technology for minimally invasive treatment of cardiac arrhythmias, a major healthcare problem affecting 5.3% of the UK population. Currently, diagnosis and treatment of cardiac arrhythmia is performed under X-ray guidance, which offers no 3D information and no soft tissue contrast as well as a procedure time of several hours, resulting in significant radiation exposure to patient and medical staff. MR-guided EP-procedures avoid radiation exposure completely and have a high potential to improve the accuracy of the EP-procedure. The key is to provide the cardiologist with images showing the myocardial tissue with superior soft tissue contrast and the position and shape of the catheter devices. For this, the positions of the electrodes and the shape of the catheter are displayed with respect to three-dimensional cardiac anatomy. However, the cardiac anatomy is dynamically changing due to cardiac and respiratory motion. Therefore, the motion must be measured and this information used to deform the pre-acquired MR-data and to display the catheter at the correct position. Furthermore, non-invasive MR-techniques were developed to quantify the size and shape of the ablation lesion. Finally, the clinical feasibility of new technology will be tested allowing further clinical trials for commercialization. The project requires a strong collaboration between industry, academia and clinical end users. This unique interdisciplinary set-up allows faster development of novel technology with a strong focus on clinical translation.

Intra-operative terahertz probe for breast cancer surgery

Awaiting Public Summary

Awaiting Public Summary

Awaiting Public Summary