The vast majority of diagnostic tests are conducted on blood samples withdrawn from the patient. In newborns particularly preterm babies, blood is not freely available and so vital diagnostic checks are compromised. Whilst non-invasive technologies are becoming available to measure blood gases nothing exists to non-invasively measure blood electrolytes (Na, K, Ca, etc.), glucose, lactate, ammonia, amino acids, drugs and their metabolites, all of which can be critical to understanding the newborns’ condition. Probe Scientific has developed a minimally invasive platform technology that enables the monitoring of blood electrolytes (Na, K, Ca, etc.), glucose, lactate, ammonia, amino acids, drugs and their metabolites, WITHOUT blood withdraw. The company has already demonstrated the suitability of its MicroEye device when in combination with online systems for continuous, automated and online real-time monitoring without blood loss in adults. This project will enable Probe to develop its NanoEye® device as a prototype suitable for use in neonates, infants and children. Resubmission