Crystallisation has traditionally been operated as a batch process, but problems with consistent product specification arise e.g. size distribution, correct polymorphic form & morphology. Consequently it has been identified that continuous flow crystallisation can improve manufacture and offer several benefits including energy and capital cost savings; leading to many flow reactors being sold for laboratory use. However due to the vulnerability of crystallisation, its implementation at an industrial scale has been restricted. Autichem have noted this gap in the market and have devised a continuous plug flow reactor that combines CSTR and tubular technology to improve heat transfer and mixing control.

Reducing the capital equipment cost of a continuous solution crystallisation system by improving the design and controllability.