Musculoskeletal (MSK) conditions affect many people, including problems in joints, bones and muscles and sometimes associated tissues such as nerves. Over 20 million people in the UK, almost 30% of the population, have an MSK condition such as arthritis or back pain. Symptoms can include pain, stiffness, limited movement, and disability, which affect independence and quality of life. There is a significant impact on people and employers, and over 30 million working days are lost due to MSK conditions every year in the UK, and they account for up to 30% of GP consultations in England. MSK conditions account for the third-largest area of NHS spend, about £5 billion each year [\[1\]][0]. By 2030, over 15.3 million people in the UK will be over 65 years of age, resulting in an ever-increasing demand for MSK services. However, in the current rehabilitation process, there are persistent challenges for both patients and healthcare providers in terms of gathering necessary therapy information and reducing the risk of the rehabilitation process. Hence, there is a strong need for an effective rehabilitation tool that provides continuous and measurable real-time gait analysis of stroke survivors at home or in hospital environments. The UK consortium will focus on developing the following advantages in this project: 1) Lightweight, (near) real-time markerless posture detection software - a mobile phone-based software platform can be a potential alternative solution to the conventional marker-based solution to assist the clinical gait assessment in/out hospital environment. 2) 5G-empowered tele-rehabilitation assessment platform - a low-cost clinical prognosis application in mobile application and 5G powered cloud computing service, to increase intelligence, computing efficiency, and power efficiency of single-camera based markerless systems. 3) End user lab validation -- as this is an end-user-focused project, our platform will be used in lab trials, which allow participants to have feedback on the system as well as formally validate the system performance using one of our golden standards marker-based 3D vision motion capture Vicon systems. Such validation data will undoubtedly increase the confidence and quality of using such a platform in healthcare trials during telerehabilitation sessions. [0]: https://www.gov.uk/government/publications/musculoskeletal-health-applying-all-our-health/musculoskeletal-health-applying-all-our-health?&_ga=2.115276103.1912366926.1697446670-288334124.1673605915#:~:text=MSK%20conditions%20account%20for%20the,%C2%A35%20billion%20each%20year.&text=The%20pain%20and%20disability%20of,family%2C%20social%20and%20working%20life

The purpose of this project is to assess the utility of Atom 5, a direct patient-facing technology provided by Aparito, to improve adherence and persistence with oral anticoagulation through increased engagement with a cohort of elderly patients with atrial fibrillation (AF), the commonest form of heart rhythm disturbance that is responsible for over 20% of all strokes. Oral anticoagulants (OACs) are highly effective in stroke prevention in AF and their increased use is an NHS priority. Increased uptake of OACs, particularly of the newer non-vitamin K-antagonist OACs (NOACs), has recently been shown to significantly reduce the annual number of AF-related strokes in England. However, concerns remain about poor adherence and persistence with OACs resulting in suboptimal stroke prevention. We found that 15% of patients do not continue their NOAC in the community after their initial 2-month supply from Barts Health NHS Trust runs out. Other UK studies have reported a similar rate of early non-persistence, increasing to 25% by 12 months. Data are as yet limited on the ability of technologies such as Atom 5 to improve healthcare, in this case through improved medication adherence and persistence, in an elderly population who may be less tech-savvy, yet it is precisely this population that potentially has most to gain from innovative approaches.This project will involve patient engagement to understand their needs and acceptability of such a solution, a clinical trial design developed in partnership with key opinion leaders and a NICE Scientific advice procedure to ensure a data generation strategy that is patient centric, feasible and able to demonstrate clinical and economical value

Epilepsy is one of the most common neurological disorders worldwide with over 500,000 suffers in South Africa (SA) alone. The prevalence of epilepsy in low to middle income countries is substantially greater than in more resourced countries - 81.7 compared with 45.0 per 100,000 and affects a younger population. Precision medicine aims to optimise therapeutic benefit to patients by understanding and responding to individual circumstances. To date, such approaches have been considered to be too expensive to roll out in emerging countries. There are no studies published on technology-based monitoring in epilepsy in Africa and very little on the genetic aetiology or pharmacogenetics of epilepsy particularly in Sub-Saharan Africa. mHealth provides the opportunity for interaction between patients, caregivers and health care professionals empower people to be partners in their or their children's health. It allows for active engagement and data that can be collated could contribute to better understanding and partnerships in a way that take public views into account. Medication adherence is a major reason for poor control in epilepsy and a challenge for caregiver's is remembering to give frequent medications that often change in dose and timing. An easy and reliable reminder is likely to improve adherence. The Aparito app allows for a visual representation of the health of affected individuals that can be shared with doctors by caregivers in real-time. The nature of the 2 way interaction could allow for health promotion messages to be shared with caregivers in their own time on a regular basis. Ill health carries a significant economic burden on families whose lives are already stressed by poverty and this initiative can allow for a better understanding of how the burden of care may be eased by allowing recording of daily realities in real time. Medical technologies have great potential but must be affordable, feasible and culturally acceptable. This study aims to interrogate the challenges and perspectives of South Africans on the use of such initiatives such as this so that implementation of any such initiative takes into account the community's view and needs. Remote monitoring and communication using cell phone technology allows for collaboration between different health care sectors and the families in an objective and reliable way if data on the affected child can be readily collated and is easily accessible to all involved in their care. This Newton Fund project is working towards the United Nations Sustainable Development Goals 3 - Good Health and Wellbeing; Ensuring healthy lives and promote well-being for all at all ages.