Globally, poor oral health and oral diseases are costing £450B and affecting over 3.5B people. Enamel erosion is a major contributor to these conditions, affecting almost 50% of the world's population. Evidence suggests that poor oral health may also be linked to non-communicable diseases such as diabetes, cardiovascular complications, and pneumonia. However, current treatments such as fluoride varnishes and remineralisation solutions only alleviate the symptoms of receding enamel. There is currently no solution available that can effectively re-grow enamel with non-toxic compounds that are easy to use and produce comparable structures and mechanical properties in a patient-friendly manner. Mintech has developed a patent-pending compound and process to create a topical varnish for teeth that can regrow enamel. This breakthrough innovation has the potential to replace preventative fluoride varnishes, regenerate eroded dental enamel, and significantly reduce the global burden of oral health diseases. To achieve this goal, this grant proposal aims to bring Mintech's current prototype into a market-ready state and prepare it for commercialisation. With the successful implementation of this project, Mintech's enamel-regenerating varnish could revolutionise oral healthcare and improve the quality of life for millions of people worldwide.

Poor oral health and oral diseases cost £450 billion globally and affect over 3.5 billion people. Nearly 50% of the global population suffers from conditions arising from enamel degradation and evidence suggests that poor oral health may be a key contributor to other non-communicable diseases such as diabetes, cardiovascular complications and pneumonia\[WHO/IBIS\]. Current alternatives such as fluoride varnishes and remineralisation solutions only treat the symptoms of receding enamel, and no solution exists that can re-grow enamel with non-toxic compounds that are easy to use, produce comparable structures, mechanical properties, using the patients' own saliva. Mintech has invented a patent-pending compound and process to create a topical varnish for teeth which re-grows enamel. This varnish may be able to replace preventative fluoride varnish, allow treatment of conditions that are currently not possible to treat and thus significantly ease oral health disease burden globally. Oral disease is the 4th most expensive illness in the world\[WHO\]. This grant-proposal aims to conduct a non-invasive in-vivo study in order to evaluate efficacy and effect sizes, perform initial health economic modelling and prepare MHRA submission and CE marking.